اثر عصاره هيدروالكلي برگ گردو juglans regia بر فعاليت آنزيم هاي AST و ALT در موش هاي صحرايي ديابتي شده با آلوكسان

Effects of hydroalcoholic extract of Juglans regia leaves on activity of AST and ALT enzymes in alloxan- induced diabetic rats

Objectives: Diabetes is a metabolic disorder characterised by hyperglycemia resulting from perturbation in insulin secretion, insulin action or both. Juglans regia (Juglandaceae) has been used in Iranian traditional medicine in the treatment of diabetes. Ill:this experience the preventive effect of hydroalcoholic extract of Juglans regia leaves. on activity ofAST and ALl! in alloxan- induced diabetic rats was investigated. Methods: In this research 18 male white Wistar rats, with body weights of 180 - 220 g were randomly allocated into three groups with six rats per grpup:first group(nondiabetic control); second group(diabetic control) and third group(diabetic rats treated with hydroalcoholic extract of Juglans regia leaves). In order to induce diabetes, alloxan was administered as a single dose(120 mgkg IBW), intraperitoneally, At the initial and the end of 2 and 6 weeks of experimental period, rats were fasted for 8h, and then fasting blood samples were collected in heparinated tubes. Sampling was performed from the orbital sinus. ReIUIts: The results indicate a significant difference in AST and ALT level in the diabetic group compared with the other groups (P