ارزيابي عصاره آبي ميوه گياه زيره سبز بر درد محيطي حاد در مدل موش كوچك آزمايشگاهي

Assessing the Effect of Aqueous Extract of the Cuminum Cyminm Seed on the Acute peripheral Pain in Hot Plate and Tail Flick Models in Mice

Background and Purpose: Cuminum Cyminm (CC) is one of the plants whose aqueous extract is used in traditional medicine as anti-convulsive, anti-epileptic and as a tretment tor some visceral pains. However, no substantial reports can be found of its effects on the peripheral pain in lab animals. Therefore, this study was condcated to determine the eefects at the IP injection of the aqueous extract of CC on the acute peripheral pain in Hot Plate (HP) and Tail Flick (TF) tests in mice. Methods and Materials: This experimental study was conducted on 56 male Albino mice (8 groups each with 7 mice) weighing 2530 gr. 200 and 500 mglkg of the aqueous extract of CC or saline of the volume were injected intraperitoeally 30 minutes prior to the tests. Pain measrment criteria in the TF test was the response time to the pain by raising the tail, and in the HP test the time to begin to lick the front legs or raising the rear feet. Results: The IP injection of the CC aqueous extract with the doses of 200 and 500 mglkg significantly increasd the response time to the pain in HP and TF tests (P<0.01) in cmparison with the control groups and the group receiving saline. The efect was however more remarkable with the 500 mg/kg dose. Conclusion: The results of this study indicated that the aqueous extract of CC reduced the acute peripheral pain in the mice.