بررسي حساسيت نايسريا گنوره به سيپروفلوكساسين

Study of the Sensitivity of Neisseria Gnorrhoeae to Ciprofloxacin

Background and Purpose: Gnorrhoeae is one of the most common sexually transmitted diseases in the developing and developed countries. This bacterium has gained some resistance agaist several antibiotics used as promary medication in the past deccade; therefore. the use of ciprofloxacin has been recommended. On the basis of reportsd on the reducation of this bacterium to ciprofloxacin, this study in conducted to determine its sensitivity. Methods and Materials: This descriptive research was condcted on the population of patients admitted to medical laboratories in Mashad, Iran, who were suspicious of having Neisseria Gnorrhoeae. They were selected by convenient sampling. 1348 cases with urethral discharge were examined from 2003 to 2004; two swaps were taken for smear and culture. After colony growth and the identification of the Neisseria Gnorrhoeae, antibiogram was performed via disc diffusion with penicilin, tetracyclin, erythromycin, and ciprofloxacin discs. Then the minimal inhibitory concentration was deetermined for ciprofloxacin. Results: 71 cases of Neisseria Gnorrhoeae were identified, of which 16.9% were sensitive to penicilln, 25.3% to tetracyclin, 67.6% to erythromycin, and 70.3% to ciprofloxacin. 6 cases were resistant to ciprofloxacin and their MIC ranged from 1 to 16 ~gr/ml. Conclusion: Since ciprofloxacin is currently the primary treatment for Neisseria Gnorrhoeae, it seems that with the increased resistance obsered in the present study, ciprofloxacin can no longer be considered as the preferred antibiotic against Neisseria Gnorrhoeae. Therefore, selt treatment without medical prescription is strongly prohibited. Vournal of Sabuvar Uoivenil)ʹ of M~i£alSciences, Volume 15, Number I, pp.46-51).