مطالعه تاثير مصرف لووستاتين بر افزايش قدرت عضلاني بيماران سكته مغزي ترومبوتيك در مسير شاخه فوقاني شريان مغزي مياني، بستري در بيمارستان گلستان اهواز

A study on the effectiveness of lovastatin in increasing muscular power in patients with thrombotic eVA in superior branch of middle cerebral artery

Objective: Stroke one of the most common diseases in neurology and is the third cause of death in old age. Impairment of motor power and other neurological deficits and imposes a significant financial burden on both patientsʹ family and health care system. The aim of the present study was to assess the effectiveness in improving the muscular power among these patients. Subjects and Methods: In this study on 100 patients (50 females and 50 males) diagnosed by history, physical examination and brain Cf-scan who had experienced thrombotic eVA on superior branch of the middle cerebral artery and had a normal lipid profile on laboratory examination and did not previously receive lovastatin therapy, were allocated into lovastatin and control groups. The lovastatin group (n= 49; 22 males and 27 females) received 20 mg/day for one month. While the control group (n= 5I; 28 males and 24 females). Both groups received usual standard treatment of thrombotic eVA (ASA 325mg/daily and dipyridamol 25mg/tds) and similar physiotherapy interventions. The muscle power at first, one week and 30 days after starting trial on each patient was measured with the same NIHSS scaling. Results: Both groups had some improvement at the end of trial but patients received lovastatin had a significantly better improvement (P