بررسي تاثير تجويز روزي يكبار جنتامايسين داخل وريدي در درمان عفونت ادراري كودكان

The effect of once-a-day dosage of gentamicin for urinary tract infection in children

Objective: Urinary Tract infection is the most common disease in children and its treatment is vital for prevention of subsequent complications. Currently gentamicin is used three-times a day as a common treatment for urinary infection, but this type of treatment has side effects. This study is done to determine thc effect of once-a-day intravascular injection of gentamicin for urinary tract infection in children. Subjects and Methods: This study is a standard clinical trial was conducted on 66 patients with clinical symptoms of upper urinary infection aged between 3 months to 12 years who were hospitalized in Razi Hospital of Kermanshah. Both groups were completely equal with regard to age, weight and other CBC indexes. In control group (n=36) ampicillin was used and gentamicin was employed 3 times a day. In experimental group (n=30), the same amount of ampicillin was used whereas gentamicin WJS administered once-a-day. The treatment duration was 10-14 days. In the first 7 days, gentamicin was injected intravasculcrly, while in the other days it was used orally. After receiving microbial sensitivity tcstx results, arnpicil lin was eliminated from treatment regimen. After termination treatment period, the patients were followed up for 6 months. Descriptive statistics and X2 and Fisher Exact Test were employed to analyze of the data. Results: 29 patients (80.5%) of control group and 24 patients (80%) of experimental group were less than 5 years old. The mean weight of patients in control and experimental groups were 15 ± 8.6 and 14 ± 9.2 kg respectively. 25 patients (69.4%) of control group and 23 (76.7) patients of experimental group were females. In most of the cases E. Coli was the responsible organism and that the most common finding in the urinary analysis of the patients was increasing the number of neutrophills. Respond to the treatment was 97.2% in control group and 96.7% in experimental group (P>0.05). The relapse rate was 29% in control group and 33.3% in experimental group. Scar was seen 19.2% in control group and 22.2 in experimental group. In analysis with X2-test, no significant statistically difference was seen between the two groups regarding relapse and scar development (P>O.05) Conclusions: Gentamicin, administration as a once-a-day treatment is equally effective as three times a day in children with upper urinary tract infection.