مقايسه دوزهاي مختلف پروپوفول براي القاي بيهوشي بر اساس پايش BIS

The Comparison of Different Propofol Dose for Anesthesia Induction Based on BIS (bispectral index) Monitoring

Abstract Introduction: Propofol is a new intravenous hypnotic drug that in combine with a short acting opioid have been used in total intravenous anesthesia (TIVA). The SIS provides additional information for standard monitoring techniques to recognize depth of sleep and achieve the appropriate dose of drug. Objective: Comparison of different propotol dose for anesthesia induction based on BIS (bispectral index) monitoring. Materials and Methods: forty five patients with ASA class l.Il who underwent surgical operation on leg fracture were randomly assigned to 3 groups. Group A with a propofol dose of Img/kg, Group H at a dose of 1.5mg/kg and Group C at a dose of 2mg/kg were studied. Remifentanyl (O.5mcg/kg) was added to propofol as opioid drug. The method of SIS index (50-60) has been used for determination of conseiousness level and the depth of sleep and tor achieving the appropriate dose of propofol. The patients were evaluated to determine occurrence of hyporensicn. bradycardia, the presence of intubation movement and the autonomic signs. Resull : The mean levels of BIS was 58.8±9.85 in the Group A, 50.2±6.55 in Group B, and 44±5.65 in Group C. Comparison between the mean levels of HIS revealed that the Group A was significantly different with the other two groups(p=0.009).Optimum level of SIS was significantly different in 3 groups .group 13 (oj(166.7), group A (%40), group C(~;o20), less than of all groups (P=0.034). Hypertension incidence following intubation in group A was 33.3~.ʹo and Group S was (%6.7)and in group C wasnʹt any hypertension which detected a significantly different between three groups(P=0.OI8). Regarding to need further propofol dose, there was a significant <.Iifference(P