بررسي ميزان تاثير روش سم زدايي سريع با نالتركسون NAD بر ترك اعتياد در معتادين مراجعه كننده به بيمارستان اعصاب و روان خرم آباد در نيمسال اول 1384

The effect of rapid detoxification method with Naltrexone on drug abuse quitting in drug abusers referred to Khorramabad Psychiatric hospital during the first half of the year 2005

Background: About 8 percent of Iranian adult population are illicit drug abusers. Affected persons grow more each day. Ominous consequences such as divorce, prostitution, murder and other crimes and infectious diseases such as AIDS and hepatitis take place following drug abuse, as well as a loss equall to 29% of national income for our country. Traditional treatment methods wasted too much time and cost. professional inpatient clinics arc not adequate for admission of all care seekers. Rapid detoxification methods are supposed to be better alternatives. Materials and Methods: 140 male drug abusers in two matched groups were assessed from March to September, 2005. They used heroin or opium. Both groups were scheduled for detoxification and were closely observed for 3 months thereafter. First group received Clonidine, Bcnzodiuzepinc and Naltrexone besides symptom relieving modalities in first 4 days of treatment. Naltrexone was continued in maintenance dose for one month. Second group received Mcthadone for one month. Results: Clientsʹ age was between 18 to 73 years, with mean age 34 years old. Their intelligence quotients were above the lower limit ofnonnal range. There was no significant difference according to these parameters between two groups. Success rate in rapid detoxification group was 55 0/r, and in Methadone group was 50 ʹ%. Relapse in rapid detoxification method occurred less frequent and slower (45 % vs. 50%). In Naltrexone group, better success rate was due to less duration of drug abuse and heroin dependency. In Methadone group, therapy had better results in patients with longer drug abuse history and opium addiction. There was no significant difference between success rate and either drug kind or job, marital status or education level. The most serious adverse effect in both groups was hypotension (10% in Naltrexone and 5 % in Methadone groups).Conclusion: Rapid detoxification with Naltrcxonc seems to be a convenient therapeutic option in less time and more volunteer size according to its high success rate and less duration and negligible adverse effects.