بررسي عوارض چشمي و عوامل مرتبط در بيماران تالاسميك مراجعه كننده به بيمارستان بوعلي سينا ساري در سال 87 - 1386

Evaluation of ocular defects and its relevant factors in patients with beta thalassemia major in Sari Boo Ali Sina hospital, (2006-2008)

Background: As There is not accurate information about ocular defects in Thalassemia Major (TM) patients in Mazandaran province .this study was designed to assess the prevalence of ophtalmopathies in thalassemic patients and also recognize its relevant factors in Sari Boo Ali Sina hospital. Sari. Materials and Methods: This descriptive Cross-sectional was Carried out on 60 TM patients in Thalassemia center at Sari Boo Ali Sina hospital. Subjects were selected by systematic sampling. After gathering demographic data, patients were evaluated about their illness and its complications from their medical records. Their visual acuity was assessed using Snell chart by an optometrist. Evaluation of retina was done by our ophthalmologist colleague. Visual evoked potential (VEP) was assessed by TOENEES instrument made in Italy which had the ability to assess both VUʹ and P300. Findings were analyzed by SPSS \ 3 software and Chi square and Mann-whitney tests. Results: 60 patients undcrwen this study that 33 of them (55%) were male. 4 of them (6.6%) had problems in visual acuity. 3 of these became normal after refractive correction. 3 patients (5%) had Inferior Posterior Cortical Cataract. 2 of them (3.3%) had punctuate lens cortical opacity and one (1.7%) had mild nuclear sclerosis. 4 patients( 6.7ʹ%) had macular pigmentation and one (1.7ʹ~0I) had left optic nerve head pit. No abnormal finding was detected in VEP. such as latency in voltage, Conclusion: Totally 20 patients had ocular complications. These defects can be a result of dcsferal toxicity or Iron toxicity and drug effects on binding to cuppcr and zinc and removing them from retinal cells or cxtrarnedulary hcmatopoesis. So based on the results, ophthalmologic evaluation of TM patients and tight dcsferal dose adjustment in these patients seems necessary.