سلول هاي استرومايي مغز استخوان و كاربرد آن در ضايعات عصبي

Bone marrow stromal cells and their application in neural injuries

Background: This article reviews experimental and clinical studies III which neural mjunes repaired with bonc marrow stromal cells. History: Bone marrow contains two kinds of stern cells: hematopoietic and nonhematopoictic (stromal) stem cell. In vitro studies indicate that bone marrow stromal cells have the capacity of differentiation into other cells (such as neural cell) under treatment with inducing agents. On the other hand. in vivo studies have shown that after transplantation of this cells into damaged neural tissues, engraft to host tissue, diffcrentiar to neural cell and improves neurological and motor function. In addition to direct injection, other noninvasive methods such as intravenous, intraventricular and lumbar puncture use for bone marrow stromal cell transplantation. Conclusion: Bone marrow stromal cells are suitable source for the treatment of neural mjunes because of easily available, immunological inert after transplantation, rapid expansion 111 culture, genc expression of neural cells and cngraftment to host neural tissue.