بررسي ميزان تحمل غيرطبيعي گلوكز و مقاومت به انسولين و بروز ديابت در بيماران مبتلا به سندرم تخمدان پلي سيستيك در شهر شيراز

The survey of abnormal glucose tolerance and insulin resistace and incidence of diabetes type 2 in poly cystic ovary syndrome patients in Shiraz

Background: Polycystic ovarian syndrome is one of the most cornmen hyper androgenic disorders affecting women, its prevalence being estimated at 5% - 10%. Our goal was to survey abnormal glucose tolerance, insulin resistance and incidence of diabetes type 2 in patients with polycystic ovary syndrome. Materials and methods: This investigation is a descriptive - analytic study which is done to survey abnormal glucose tolerance, insulin resistance and incidene of diabetes type 2 in polycystic ovary syndrome (PCOS). This study included 150 patients with the diagnosis of PCOS. These patients were chosen by target bascd sampling. Among the subjects, laboratory tests were performed for 125 patients. Questionnaire, fasting blood suger test, fasting insulin and glucose tolerance test by 75gr glucose, were used as data gathering tools. The results of the blood suger test were interpreted using the WHO 1999 criteria. Results: The results of oral and glucose tolerance test showed 14. 4 percent of the patients had impaired fasting glucose and 4 percent of the patients had diabetes type 2 (FBS> 126mg/dl). Insulin resistance was seen in 9. 8 percent of the patients. 7. 2 percent of the patients had impaired blood suger after two hours (140-199 mgfdl) and O. 8 pcrsent of patients had diabetes type 2 (200)mg/dl). Conclusion: level of fasting blood suger and insulin and ratio of fasting blood suger to fasting insulin were good markers for diagnosis of insulin resistance. American diabetic association recommended for the care of young women with PfOS, screening for impaired glucose tolerance and diabetes type2.