تاثير اواركتومي و جايگزيني استروژن بر وزن بدن و چربي احشايي موش هاي صحرايي

The Effect of Ovariectomy and Estrogen Replacement on Body Weight and Visceral Adipose Tissue in Rats

Introduction: Estrogen deficiency is associated with unfavorable changes in body composition and abdominal fat deposition. The consequences of these changes lead to metabolic abnonnalities and differential fat distribution. Materials and Methods: Seventy female Wistar rats (weight: 170.73±15.82gr; mean±SD) were divided into 7 groups:lntact(one group),sham (two groups), ovariectomized (two groups), ovariectomized, receiving estradiol valerate(one group) and ovariectomized, receiving sesame oil (one group).The intact rats were anesthetized and visceral fat was then taken from the abdominal cavity and weighed immediately. Two weeks after operation, one group of ovariectomized rats and one group of sham rats were sacrified and visceral fat was measured. The estradiol receiving ovariectomized group and vehicle group were given equal volumes of 1713~stradiol(301J9/kg,sc, 5 d/wk) and sesame oil for 8 weeks, respectively. After 8 weeks, all animals were sacrificied and intraabdominal fat depots were dissected and weighed. Data were analyzed with one-way ANOVA and posthoc and using paired t test. The differences were considered significant at P