تاثير جريان مستقيم ميكروآمپر بر التيام زخم پوستي در خوكچه هندي

Effect of Micro-Amperage Direct Current on Skin Wound Healing in Guinea Pig

Background and Objectives: Micro-amperage direct current (MADC) has been used for a long time to accelerate the wound healing. The purpose of this study was to determine the mechanism of effectiveness of the MADC on skin wound healing, To do that, the comprehensive evaluation of the wound surface, mechanical properties, and histological findings of healing stages were studied. Material and Methods: Fifty-one male guinea pigs were randomly divided into 3 groups: one control group and two treatmet groups (anodal and cathodal groups). A full thickness skin incision, with a length of2.5 em, was performed on the dorsum of each animal at a distance of I ern to spinous processes. A day after incision and up to 3 weeks, every second day, MADC with the relevant polarities was applied to the incision area. The wound surface and its mechanical properties were measured. Additionally, histological findings were studied. Results: The wound surface area was significantly decreased (P