بررسي ارزش تشخيصي رنگ آميزي AGNOR و ميزان بروز KI-67 MIBI در تومرهاي عضله صاف رحم

DIAGNOSTIC VALUE OF AgNOR STAINING AND Kh7 (MIB1) EXPRESSION IN UTERINE SMOOTH MUSCLE TUMORS

Background & Aims: Uterine smooth muscle tumors are the most common human neoplasm They are divided clinically as benign and malignant but there is another group of lesions which is difficult to place in these two categories, so-called STUMP and differentiation of these tumors on the basis of H&E staining is difficult. The goal of this study is to find distinguishing objective biomarker and a survey of proliferation markers comparing these three groups of tumors. Materials &Methods: Twenty one cases in each group of the above mentioned tumors were selected randomly from pathobiology laboratories and studied by using IHC staining for Ki_67 expression and AgNOR method. Results: Ki_67 was expressed in 63.15% of leiomyosarcomas, 4.76% of STUMPs and 0% of leiomyoma group. Ki_67 expression between leiomyosarcoma and STUMP, and also between \eiomyosarcom and leiomyoma were significant (P