بررسي اثر عصاره آبي الكلي ميوه گياه بادمجان Solanum me;ongena L بر درد مزمن در موش سوري نر

The effect of Solanum melongena L. hydro-alcoholic extract on chronic pain in male mice as compared with morphine

Nowadays, steroidal anti inflammatory and opioide analgesics are widely used to attenuate the chronic Pain. For achieving new analgesics, many investigations have been focused on understanding the antinociceptive effects of different ethnic medicinal plants. In this study, the effects of Solanum melongena L. extract on chronic pain is assessed and compared with morphine. This study was conducted as an experimental trial on 40 male mice, equally and randomly divided in to 8 groups. IS minutes after intra peritoneal injection of the extract, morphine or saline, 251ʹ1 of 2.5% formalin was subcutaneously injected to left hind paw of each mouse. Immediately after this injection the animals were placed under a chamber on the formalin test observational set up. Then pain scores were ascribed to each mouse according to pain intensity expression every IS seconds during 1 hour. Our findings showed that 1000mglkg Solanum melongena extract was analgesic in the I" (acute) and the 2"ʹ (chronic) phases of formalin test. This effect was more prominent during 20 to 40 min. after formalin injection and the pain score was significantly less than control (p=000). The analgesic effect of this eggplant dose, didnʹt show any significant difference with 4mglkg morphine sulfate in this time period (P=0.146). According to our findings the hydro-alcoholic extract of Solanum melongena reduces chronic pain produced by formalin injection.