بررسي اثرات عصاره آبي - الكلي برگ گياه پونه بر روي فاكتورهاي عملكردي كبد در موش صحرايي نر

Assessment of the Effects of the Hydro-Alcoholic Extract of Mentha Pulegium Leaves on Liver Function Test in Male Rat

Liver is one of the vital organs which has a key role in regulating most physiologic mechanisms, and any disorder in hepatic function can cause a series of physiologic and anatomical disorders and still other diseases. Since Mentha pulegium has been used extensively in traditional medicine, the aim of the present investigation is to study of the effects of the Hudro-Alcoholic Extract of the Mentha Pulegium Leaves on hepatic functions. Methods and Materials: In this experimental study, 50 Wistar male rats (about 220- 230 g) were used in five groups of tens including: control group receiving nothing, sham group receiving distilled water and 3 experimental groups receiving 400, 800, and 1600 (mg/kg) of the Hydro-Alcohol Extract of Mentha Pulegium Leaves respectively. The obtained data were analyzed by t-test using SPSS and Microsoft Excel. Results: According to the results, there is a significant reduction in the level of ALT, AST in experimental groups. In addition, the level of ALP showed a significant increase. Regarding albumin and total protein, there has been a decline in the experimental groups receiving the highest dose of the extract, and asignifilant reduction in the total body weight in proportion to the increased dosage of the extract. Conclusion: The Hydro-Alcoholic extract of mentha pulegium leaves probably has a significant effect on hepatic function. This effect may be due to the presence of Flavonoids (Hesperidin, diosmine), antioxidant, tannin and pulegone in the extract. This effect is reflected in the reduction of ALT, AST and the increase in ALP. Also, it can be attributed to the decrease in the hepatic serum level of the albumin and total protein