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The study of the serum manganese concentration in the bladder cancer patients in comparison with healthy subjects

Manganese (Mn) is one the more important trace elements in the hu­mans. Mn plays an important role in antioxidant defences and it is an essential cofactor for a number of enzymes. Some studies have re­vealed that Mn deficiency is teratogenic. The relationship of Mn defi­ciency and cancer induction also has been studied in some studies. We evaluated the serum Mn concentration in patients with bladder cancer in comparison with healthy individuals. During this cross sectional study, 51 patients with bladder cancer and 58 normal subjects were selected regarding the inclusion and exclu­sion criteria. Blood samples were collected after 8 hours of fasting. The Mn serum concentration was measured in all samples and co- pamared between two groups. Mean of serum Mn concentration was 1.3 ± 0.39 jug/1 in bladder can­cer patients and 1.87 ± 0.84 |ug/l in control group. There was a signifi­cant difference between two groups (p < 0.001). According to the results of this study Mn serum concentration had sig­nificant decrease in bladder cancer patients in comparison with normal subjects. This result is similar to the other researches done in different cancers. Regarding the high Mn level in fresh foods and vegetables, consumption of these nutrients, is recommended in high risk individu­als for bladder cancer