ادم پري تومورال همراه مننژيوم ها، نقش رسپتورهاي استروئيدي و مشخصات راديولوژيك

The role of steroid receptors in and pretumoral edema accompanying meningiomas

Background: Meningiomas are considered extra-axial and benign tumors. Though they are pathologically classified as benign, non-benign and other types, it seems that information derived from this classification cannot explain the behavior of the tumor. Pretumoral brain edema (PTBE) is one of the signs that has been less thoroughly studied, and still there is not a single consensus about its mechanism. Despite the benign and extra-axial manifestations of meningioma, in more than 60% of cases, these tumors have PTBE. The goals of this study were to show the role of the level of progesterone positivity in tumor cells as a behavioral factor and to find different features in the MRI and CT scans of meningioma patients that might be related to this issue and also to PTBE. Materials and methods: In this study, 77 patients with intracranial meningiomas who referred to the Neurosurgery Department of Imam Khomeini Hospital in Tehran were followed prospectivity between 1999-2003. Initial CT scans andMRIs (Tl, T2) including the diameter, volume, location, contour, presence or absence of PTBE, and factors with surgical and pathological findings, clinical presentations, and immunohistochemical (EHC) staining for estrogen receptors (ER) and progesterone receptors (PR) were carried out. Results: Tumors with higher PR levels had smaller sizes, and their contours were smoother. Images showed that these tumors were less invasive, in that in more than 50% of the cases, the arachnoid space (AS) around the tumor could be observed, and it was less probable to see PTBE. Instead, the duration of the disease was longer, and the intrasurgical bleeding was less. Conclusions: The results of this study show that the future behavior of intracranial meningioma tumors cannot be predicted based on such features as diameter, location, cells in order to predict the future behavior of these tumors.