اثر عصاره ريشه گياه آدمك ( Biebersteinia multifida DC) بر كاتاتوني ناشي از پرفنازين در موش سوري

Effects of biebersteinia multifida dc root extract on perphenazine-induced catatonia in male mice

Catatonia is one of the major signs of Parkinsonʹs disease due to impaired dopamine in extrapyramidal system. So far, effects of many plants on neuronal and movement disorders have been evaluated, some of which are accepted in clinical studies. In the present research, the effect of Biebersteinia multifida DC root extract oil perphenazine -induced catatonia in male mice was studied. The root extract (10, 25, 50,100 mg/kg) was orally administered to mice for two weeks. Control group received water for two weeks, as well. One hour after the last dose, perphenazine (5 mg/kg) was administered (IP) to induce catatonia. Muscular rigidity of animals was determined by scoring method of Morpurgo. Results showed that Biebersteinia multifida DC root extract at doses 10, 25 and 50 mg/kg increased rigidity while administration of higher dose of 100 mg/kg could improve muscular rigidity. Therefore, it is concluded that Biebersteinia multifida DC, at low doses, probably, by blocking D2 receptors in dopaminergic pathways (mesocortical-mesolimbic) potentiates perphenazine -induced catatonia, and in higher dose, reduced signs of perphenazine-induced catatonia probably via effects on dopaminergic system in nigro-striatal pathway.