تاثير مكمل روغن هاي ماهي بر شاخص هاي استرس اكسيداتيو زنان باردار

The effect of fish oil in oxidative stress indices in healthy pregnant women

Background and aim: Poly unsaturated long chain fatty acids (LCPUFAs), including docosahexaenoic asid (DHA), are susceptible to lipid peroxidation because of their high degree of unstauration. As a result they may have the ability to increase the degree of oxidative stress. In this study we evaluated the effect of omega 3 in healthy pregnant women in oxidative stress indices. Methods: This is a random clinical trial double blind study, which was performed in the governmental health service centers. One hundred pregnant women were selected and randomly divided into two groups of case and control (50 in each group). Case group was given 1000 mg fish oil (180 mg EPA، 129 mg DHA), but control group received routine cares. Blood samples (5 ml) were collected from brachial vein during 37-40 weeks of pregnancy lipid peroxide and antioxidant capacity and thiol group were measured. Data were analyzed by χ2 and t-tests using SPSS software. Result: The mean lipid peroxide in case and control groups was 2.7±1.8 and 3.29±2.14 nmol/ml, respectively which was not significant (P>0.05). In addition, mean thiol groups was 0.33±0.19 and 0.28±0.26 nmol/ml in case and control groups, respectively which was not significant (P>0.05). However, a significant difference was observed between two groups for mean total anti oxidant capacity (1.5±1.3 vs. 0.71±0.45 mol/ml) (P<0.001). Conculsion: This study showed that that fish oil usage during pregnancy didn’t produce oxidative stress in mothers.