اثر عصاره الكلي كاكل ذرت( .zea mays l ) بر جلوگيري از كريستاليزاسيون اگزالات كلسيم در in vitro

Effect of ethanolic extract of Zea mays L. on prevention of calcium oxalate crystallization in vitro

Urolithiasis is a worldwide problem, sparing no geographical, cultural, or racial groups. Kidney stones are composed of inorganic and organic crystals amalgamated with proteins. Crystallisation and subsequent lithogenesis can happen with many solutes in the urine. Calcareous stones are still by far the most common nephroliths accounting for more than 80% of stones. In Iranian folk medicine, many plants are used for treatment of kidney stones. In the present study, effect of ethanolic extract of Zea mays tuft on calcium oxalate crystallization in vitro was studied. At first, ethanolic extract of plant at doses of 0.25, 0.5, 1, 2 and 4 mg/ml were prepared. Calcium oxalate crystallization was induced by adding sodium oxalate to urine samples of 6 men. Calcium oxalate crystallization in absence or presence of plant extract was compared. The present results showed that the plant increased number of crystals in comparison to control samples. On the other hand, the plants increased small crystals, while decreased big crystals in experimental samples. Also, the plant increased mono-hydrate calcium oxalate crystals in comparison to di-hydrate calcium oxalate crystals. So, Zea mays is a good candidate for prevention of calcium oxalate crystallization.