مقايسه تاثير چهار داروي فنتانيل، آلفنتانيل، سوفنتانيل و رمي فنتانيل بر متغيرهاي هموديناميك در زمان لوله گذاري ناي در كودكان: كارآزمايي باليني تصادفي دو سويه كور

A comparison between the effects of Fentanyl, Alfentanil, Sufentanil and Remi-fentanil on the hemodynamic parameters during endotracheal Intubation: A Randomizer! Clinical Trail

Background: During induction of general anesthesia, a rapid and short-acting opioid is administered to suppress the pain caused by endotracheal intubation. In this study, it has been compared the effects of the four opioids Fentanyl, Alfentanil, Sufentanil and Remi-fentanil on the changes in arterial blood pressure and heart rate following inducation of GA and endotracheal intubation in 1-6 year old children. Materials and Methods: 80 children between 1-6 years old, who were in ASA Classes 1 & 2 and were candidates for elective surgical procedures, entered a double-blind randomized clinical trial (RCT) and randomized between 4 groups. Hemodynamic parameters were measured before induction of GA; then induction and endotracheal intubation performed and agin after 1 minute, hemodynamic parameters were measured and recorded. Results: Changes in the Sys. BP were significantly different (p=0.006) < between four groups and fentanyl had the least and sufentanil had the most changes. Similarly, changes in the Diastolic BP were significantly different (p=0.013) between four groups and fentanyl had the least and sufentanil had the most changes. Changes in the heart Rate were not significantly different (p=0.153) between four groups; although Fentanyl had the least and alfentanil had the most changes. Conclusion: According to the findings of this study, fentanyl is associated with the least changes in hemodynamic parameters in children.