بررسي ايمونوهيستوشيميايي بيان MIB-1 در فوليكول دنداني و كيست دنتي ژروس

Ininiunohistochemical Evaluation of MIB-1 Expression in Dental Follicle and Dentigerous Cyst

Introduction: The aim of this survey was immunohistochemical evaluation of MIB-1 expression in dental follicle and dentigerous cyst regarding to the capability of neoplastic changes and ability for more proliferation and more recurrence after enucleation in dentigerous cysts. Materials & Methods: Sections taken from paraffined block of 12 cases of dentigerous cyst and 12 cases of dental follicle were stained with MIB-1 antibody, using immunohistochemical method. The observing of all of the stained sections was done according to Hscore gradation and a degree of staining intensity of epithelial cells and the percent of stained epithelial cells were considered. Then the aggregate these two were announced as the final score. The data were analyzed by Mann-Whitney test. Results: The expression of MIB-1 in dentigerous cyst was greater than dental follicle (PcO.OOl ). This difference was significant for the percentage of stained epithelial cells (P=0.001) and it was greater in dentigerous cyst. Conclusion: The expression of MIB-1 in dentigerous cyst was greater than dental follicle. This difference may are attributed to the capability of neoplastic changes and ability of proliferation in epithelium layer of dentigerous cyst and different clinical behavior of dentigerous cyst.