مقايسه سطح سرمي سرولوپلاسمين در حاملگي طبيعي و پره اكلامپسي

Comparison of serum ceroiuplasmin in preeclampsia and normal pregnancy

Background: Preeclampsia is a disorder of pregnancy with increased maternal and fetal morbidity and mortality. Endothelial cell dysfunction is important in the pathogenesis of preeclampsia. An imbalance between free radical induced lipid preoxidation and antioxidant system such as ceruloplasmin has been suggested as a possible pathogenic factor in preeclampsia and disturbing endothelial function. The aim of this study is to compare serum ceruloplasmin level in preeclampsia and normal pregnancy. Methods: This is a cross-sectional study that was performed on 39 preeclamptic patients (21 mild and 18 severe preeclampsia as case group) and 30 women with normal pregnancy (control group). Five cc of blood was obtained from each patient and serum ceruloplasmin level was measured with special kit. Data were analyzed by oneway ANOVA Kruskal-wallis tests and ROC curve. P<0.05 was considered statistically significant. Results: Maternal serum ceroloplasmin level was significantly different between the studied groups (P=0.47). Conclusion: increased serum ceroloplasmin level can be used as a predictive factor to diagnose severe preeclampsia.