بررسي اثر مهاري ترشحات جوانه ي گياه Sorghum bicolor (L.) Moench بر روي توليد پيگمان پيوسيانين باكتري PTCC 1430 Pseudomonas aeruginosa

Effect of exudates of Sorghum hieolor (L.) Moench seedlings on production of pyocyanin pigment in Pseudomonas aeruginosa PTCC 1430

Most of the gram negative bacteria, secrete signal molecules called N-acyl homoserine lactone (AHL). These molecules have regulatory effects on many of bacterial genes. This regulatory mechanism which is cell-density dependent is called "Quorum sensing". Pseudomonas aeruginosa is an opportunistic pathogen that uses quorum sensing to control many of its cellular functions such as production of virulence factors. One of these factors is pyocyanin pigment. This compound has been shown to disrupt the beating of human cilia and inhibits lymphocyte proliferation. Various species of higher plants secrete substances with AHL mimic activity. These compounds can inhibit quorum sensing controlled phenotypes. In this study, we examined the inhibitory effect of exudates of Sorghum bicolor (L.) Moench seedlings on the synthesis of pyocyanin in P.aeruginosa PTCC 1430 and we found that the exudates of seedlings ofʹthis plant are able to prevent the synthesis of pyocyanin, but have no inhibitory effect on the growth of bacteria.