اختلال عملكرد تيروييد در حوالي يايسگي

Thyroid Dysfunction in Perimenopausal Women

Background: There are mild changes in Hypothalamous - piuitary -thyroid axis with aging that may be accompanied with thyroid dysfunctions without clinical manifestation. The aim of this study is evaluation thyroid dysfunction in perimenopausal women. Methods: This is a cross-sectional descriptive study that was performed on 100 women at the age of 40-60yr, who had referred to Gynecology and Menopausal clinic of Ghaem hospital, Mashhad University in 2005. At first , a questionnaire including clinical symptoms was completed ,then patients were submitted to laboratory tests including T3,T4,T3 RU,TSH,TG (triglyceride), HDL-cholesterol and LDL cholesterol. The information was analyzed by %2 and fisher exact tests. (P<0.05) was considered as statistically significant. Findings: In this study the prevalence of subclinical hyper and hypothyroidism was 5% and 1% for overt conditions. In the women of 51-60 yr ,the prevalence of subclinical hypothyroidism was 6.25%. There was an increasing levels of TG in 20% of subclinical hypothyroidism and 13.64% of euthyroidism. There was also an increase in serum LDL cholesterol levels in 40% and 22.73% of two groups, respectively (P=0.001). Subclinical hyperthyroidism group was not different from normal group in the view of menstrual disorders. Conclusion: subclinical thyroid dysfunction increases with aging and is relatively common in women. It is recommended that all aged women , should be gone under screening test for thyroid dysfunction.