بررسي تأثير ناپروكسن در كاهش درد بعد از جراحي CABG در بيمارستان دكتر حشمت رشت در سال 1386

Effect of Naproxen in treatment of post operative pain after CABG

Background: While opioids provide excellent analgesia undesirable side effects such as respiratory depression, nausea and vomiting, constitute major limitation. As a result many surgical centers use NSAID as analgesia adjuvant. The aim of this study was to examine the efficacy of Naproxen in treatment of post operative pain after CABG. Materials and methods: This is a randomized double blinded clinical trial study which performs in Heshmat Hospital in Rasht. 64 patients scheduled for elective CABG surgery were enrolled in this study. Patients were divided into 2 groups postoperatively: Naproxen group (n=32) and placebo group (n=32). One dose of drugs (placebo or 500 mg naproxen) was given (rectal supp.) immediately before tracheal extubation and second dose 12 hr later. Post operative pain was assessed and recorded using VAS within 24 hr after tracheal extubation per 3 hr. Pain was treated with 2 mg morphine IV repeated every five minute until pain score was < 3. Mean morphine consumption in the 24 hr was reduced in naproxen group (2.11± 2.4 mg) when compared with placebo group (15.16 ± 3mg). In this study the incidence of post operative nausea and vomiting was reduced in Naproxen group. Results: This study show: Naproxen is an effective drug for treatment of post operative pain after CABG and can reduce PONY incidence.