اثر مصرف خوراكي سير كوهي بر يادگيري و حافظه موش صحرايي ديابتي

Effect of Allium schoenoprasum L. feeding on learning and memory in diabetic rats

Aims. The effect of chronic oral administration of Allium schoenoprasum L. (AS) on learning and memory in diabetic rats investigated. Materials & Methods. Male wistar rats divided into control, AS-treated control, diabetic and AS-treated diabetic groups. For evaluation of learning and memory, initial (IL) and step-through latencies (STL) determined at the end of study using passive avoidance test and alternation behavior percentage obtained using Y maze. Results. STL significantly decreased in diabetic (p<0.01) and AS-treated diabetic (p<0.05) groups and the existing difference between these two group was not significant. Alternation percentage was significantly lower in diabetic group relative to control (p<0.01) and treated diabetic groups showed a significant difference in comparison with diabetic group (p<0.05). Conclusion. Although AS treatment could not enhance the capability of consolidation and recall in diabetic animals, but could improve spatial memory in diabetic animals.