تأثير تعاملي تمرين با وزنه و بارگيري كراتين بر شاخص هاي سرمي آسيب سلولي مردان غيرورزشكار

Effect of weight-Training and Creatine Loading onThe Cellular Damage Indices Enzymes Activity in Non-Athletic Male

The purpose of this study was to determine the effect of eight weeks resistance training on muscle strength, lean body mass, serum myostatin, GASP-1, IGF-I and IGFBP-3 in untrained young men. Sixteen young men (19-26 years) were assigned to resistance training (n=8) or control (n=8) groups. The training protocol consisted of thrice weekly using three sets of eight to ten repetitions at 60-70% of 1RM for whole-body exercises, whereas control group performed no resistance training. Blood sampling, muscular strength test and body composition analysis (DEXA), were performed at 0, 4th and 8th weeks. Myostatin, GASP-1, and IGFBP-3 measured by enzyme immuno assay, wherease IGF-I was determined via immunoradiometric. Result showed that resistance training caused significant increases in muscular strength [between weeks 0 and 4 (P<0.05), and weeks 4 and 8 (P<0.05)], lean body mass [between weeks 0 and 8 (P<0.05)] and GASP-1 [between weeks 0 and 8 (P<0.05)], whereas myostatin were decreased [between weeks 0 and 4 (p<0.05), and weeks 4 and 8 (P<0.05)]. But significant change in serum levels of IGF-I and IGFBP-3 did not observe. The findings of this study suggest that 8 weeks resistance training does not alter serum levels of IGF-I and IGFBP-3, and decreasing myostatin production and inhibitation of its function by GASP-1 may play important role in increasing muscle strength and muscle mass which induced by resistance training.