اثر توأم تمرين استقامتي و عصاره آبي زيره كوهي بر چربي هاي پلاسما در موش هاي سوري نر هيپر كلسترولميك

The Effect of Co-administration of Aquous Extract of Bunium Persicum and Endurance Training on Plasma Lipids in Hypercholesterolemic Male Mice

Background and Objectives: The effect of endurance training on lipid profile and cardiovascular endurance in normal rat after Bunium Persicum Extract (BPE) administration has been previously investigated. In the present study, the effect of co-administration of endurance training and persicum extract on plasma lipid and lipoproteins in hypercholesterolemic male mice was examined. Material and Methods: In this experimental study, 60 male mice were, randomly, divided into 4 groups: Vehicle, Endurance Training (ET), Bunium Persicum Extract Administer (BPEA) and ET-BPEA group. The Exercise protocol was performed at a speed of 18 m/min, 40 min/day, 5 day/week for 6-weeks. The Bunium Persicum Extract was also administered in the same period and the desired dose (0.8 mg) was reconstituted in 0.4 ml of distilled water. The amount of Triglyceride (TG), Total Cholesterol (TC), HDL-c, LDL-c and Body Weight were registered at the beginning and also at the end of the 6 weeks. Data were analysed using one-way ANOVA method. Results: The results indicated that the 6-week endurance training accompanied by Bunium Persicum aquous extract administration reduced TC (pretest; 297.7±37.08, post test; 146.1±30.8, p=O.O 19) and LDL-c concentrations (pretest; 151.8±14.4, post test; 0.12±8.7, p=O.OOI). On the other hand, Bunium Persicum aquous extract administration increased HDL-c concentration significantly (pretest; 75.9± 12.1, post test; 119.9±17.9, p=0.003). Furthermore, the results showed that body weight changes were not significant. Conclusion: These results suggest that co-administration of BPE and ET could significantly affect plasma lipid and lipoproteins. Therfore performing such program maybe useful for preventing cardiovascular diseases.