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Liver Involvement in a Patient with Familial Mediterranean Fever: Case Report

Familial Mediterranean Fever (FMF) is a hereditary syndrome characterized by recurrent attacks of fever and serositis. Liver involvement in FMF has been reported in association with amyloidosis or rarely with vasculitis. In this report, a 32 year-old man with recurrent attacks of fever, abdominal pain and arthralgia is described who had moderate increase in liver transaminases only during disease flares. FMF was diagnosed based on clinical picture, positive MEFV mutation and response to colchicine. Meanwhile, liver enzymes normalized after colchicine treatment. Despite a thorough work up, no known underlying liver disease was found to account for transaminitis. It seems that the only explanation for abnormal liver enzymes in this FMF case is transient hepatitis during FMF attacks which has already been described in few case reports on liver involvement in FMF.