بررسي اثر ضد دردي عصاره الكلي برگ گياه جعفري (Petroselinum crispum L) در موش هاي كوچك نر بالغ آزمايشگاهي

Antinociceptive effects of ethanolic extract of parsley {Petroselinum crispum L.) leaves in mice

Background: Pain is a sensorial modality, which in many cases represents the only symptom for the diagnosis of several diseases. Due to addictive properties and side effects of morphine, there is less attention to use it. Medicinal plants are used increasingly in the treatment of painful illnesses. The aim of this study was to evaluate the analgesic activity of ethanolic extract of parsley leaves in mice. Materials and methods: In this experimental study, analgesic activity of ethanolic extract of parsley leaves was evaluated in mice by formalin test and acetic acid test. Ethanolic extract of parsley leaves (at doses 100, 150 and 200 mg/kg) and morphine (10 mg/kg), as a standard drug, were injected intraperitoneally. The control group was administered saline as vehicle of ethanolic extract. Results: Ethanolic extract of plant decreased both phases of pain in formalin test. Also, it decreased number of abdominal muscle contraction in Writhing test. Conclusion: The present study indicated that ethanolic extract of parsley leaves has analgesic effects on mice and further studies need to evaluate its clinical properties