كليدواژه :
لاموتري ژين , مرفين , موش صحرايي , درد
چكيده لاتين :
Lamotrigine is a novel potential antiepileptic drug, which is not structurally dependent on the current antiepileptic drugs; it has fewer side effects too. The present study intends to assess the effects of Lamotrigine on the antinociceptive activity, induced by morphine, by using the formalin test as a test of nociception.
Methods and Materials: This experimental study was conducted on 56 adult male rats. The animals were divided into seven groups of eight rats, considered as one control, one sham and five experimental groups (one group receiving 2mg/Rat of morphine alone, three groups receiving 2mg/Rat morphine accompanied by Lamotrigine in doses of 25, 50 and 75 mg/Rat and the fifth group receiving only 75 mg/Rat of Lamotrigine alone). The drugs were intraperitoneal^ injected 15 minutes before the formalin test. The sham group received the same volume of physiologic serum, and the control group received formalin alone. The study data were analyzed in SPSS using Tukey and Kruskal Wallis test; level of significance was considered to be 0.05.
Results: Mean pain score following the injection of maximum dose of lamotrigine together with morphine was 0.08±0.001, which indicated more local analgesic effects at the acute phase in comparison with the injection of morphine alone (0.11±0.0005) (p<0.05). Also, mean pain scores following the injection of different doses of lamotrigine (25, 50, 75 mg/rat) together with morphine were 0.08±0.007, 0.06±0.0004, and 0.06±0.002 respectively, which caused a significant reduction in the pain scored the chronic phase of formalin test in comparison with morphine alone (0.09±0.0005) (p<0.05).
Conclusion: Prescription of lamotrigine accompanied with morphine, in comparison with the prescription of each alone, has better effects on the process of pain score reduction. (Quarterly
Journal of Sabzevar University of Medical Sciences, Volume 16, Number 2, pp.72-78).
