چكيده لاتين :
Since narcotics and benzodiazepine cannot be applied for cesarean anesthesia due to the effect of respiratory depression on the infant, parturients generally experience hemodynamic changes in general anesthesia. Remifentanil is a very short-effected narcotic which can be metabolyzad in the infantʹs body, and is expected not to cause respiratory depression. Therefore, the present study intends to examine the effect of remifentanil on parturientsʹ hemodynamic changes.
Methods and Materials: This clinical trial was conducted on 72 full term parturients with ASA physical status I and II , who were randomly assigned into two groups. Before the induction of anesthesia, the first group received 0.75 |i/gkg remifentanil followed by its infusion of 0.10 |ig/kg. The second group received bolus and infusion of normal saline. Heart rate, systolic, diastolic and mean arterial blood pressure were measured before the induction of anesthesia, before laryngoscopy, as well as 1, 3, 5, 15 and 30 minutes after intubation. For dat analysis, independent sample t-test, Mann Whitney U, Chi-square and paired sample t-test were used in SPSS.
Results: No significant differences were found between the two groups as for heart rate, systolic, diastolic and mean arterial blood pressure in baseline measurement (p>0.05). After remifentanil administration, mean heart rate before laryngoscopy as well as 1, 3, 5, 15 and 30 minutes after laryngoscopy were significantly lower than the placebo group. However, systolic, diastolic and mean arterial blood pressure were lower in the first group only on occasional minutes.
Conclusion: The present study suggests that the mentioned dosage of remifentanil does not have sufficient clinical effects on controlling parturientsʹ hemodynamic responses during general anesthesia for cesarean section. (Quarterly Journal of Sabzevar University of Medical Sciences, Volume 16, Number 2, pp.94-99).
