بررسي ارزش پيشگويي كننده ميزان هموگلوبين و هماتوكريت سه ماهه دوم بارداري در تشخيص پره اكلامپسي

Prediction Value of Hemoglobin and Hematocrit Concentration during Second Trimester in Diagnosis of Preeclampsia

Int roduction: Preclampsia is the most common cause of mortality among pregnant women. Recent researches show homodynamic, coagulation and metabol ic abnormalities prior to the onset of preeclampsia. The aim of this research is to evaluate predictive values of increased levels of hemoglobin and hematocrit in second trimester and occurrence of preeclampsia. Methods: In this prospective study, 60 pregnant women who referred to Ghaem hospital during 2007 were divided into two groups; 30 pregnant women in peeclampsia group whom were diagnosed as preeclampsia and 30 normal pregnant women who had normal blood pressure. Both answered demographic and pregnancy characteristic questionnaires. Hemoglobin, hematocrit , preeclampsia indicators and delivery characterist ics were recorded and data were analyzed by Mann-Whitney U, Chi square and independent t-test using SPSS. Results : There were significant differences between two groups in their hemoglobin and hematocrit concentrations in second trimester (p<0/002). The mean of hemoglobin in preeclampsia group was 13/3± l/ 1, whereas in normal group it was 12/2±1/3 gld\. Hemoglobin level of more than 12/5 gldl represented the 72/4% of sensitivity and 57/1% of specificity in prediction of preeclampsia. Hematocrit of more than 37% had sensitivity of 65/5% and specificity of 61/9% in that prediction. Conclusion: Increased levels of hemoglobin and hematocrit concentration in the second trimester were associated with higher incidence of preeclampsia. Therefore, further comprehensive and precise studies considering other predicting factors along with prospective researches in prenatal clinics are recommended.