نارسايي طولاني مدت عملكرد كليه در بيماران پيوندي با اختلال عملكرد مزمن

LONG-TERM KIDNEY FUNCTION DISEASE IN RENAL TRANSPLANTATION WITH CHRONIC ALLOGRAFT DYSFUNCTION

Background & Aims: Chronic Allograft Dysfunction is a major concern for graft loss in Renal Transplant Recipients. This paper investigated the waiting time and death-censored graft survival in renal transplant recipients with chronic allograft dysfunction. The association between short-term and long-term kidney function in this patients were studied. Materials & Methods: In a single-center retrospective study, 214 renal transplant recipients with chronic allograft dysfunction were investigated at Urmia University Hospitals from 1997 to 2005. Kidney function at each visit was assessed with GFR. We applied NKF and K/DOQI classification of chronic kidney disease staging system to determine stage of kidney disease in this group of patients. Kaplan-meiers survival analysis and log-rank test were used for data analysis. Results: The pure death-censored graft loss was 26.6% with the mean waiting time of 81.7 months. In overall, death-censored graft loss in Pts with stage 3 at the beginning of the study (start of chronic allograft dysfunctionʹs process) is faster than other Pts. Conclusion: The findings show that kidney function in the first year after transplantation is one of the main prognoses on death-censored graft loss. Therefore, care of renal transplant recipients in the first year increases long-term kidney survival.