بررسي ميزان مصرف پتدين در دريافت كنندگان گاباپنتين پس از عمل جراحي

Pethidine requirement in postoperatively gabapentin administered patients

Background: Preliminary clinical studies have suggested that gabapentin may produce analgesia and reduce the need for opioids in postoperative patients. The aim of the present study was to investigate the opioid-sparing and analgesic effects of gabapentin administered during the first 24h after surgery. Materials & Methods: In a randomized, single-blind study 196 patients assigned to two groups receiving gabapentin (n=102) or placebo (n=94). Oral gabapentin 1200 mg or placebo, 2h before surgery, followed by oral gabapentin 600 mg or placebo 8, 16 and 24 h after the initial dose. Patients requesting analgesia received it with pethidine at dose of 25 mg (iv). Total pethidine consumption for each patient was recorded from zero to 24h postoperatively. Pain was assessed on a visual analogue scale (VAS), and vomiting, dizziness and somnolence were assessed. Results: Gabapentin reduced total pethidine consumption (P<0.001) and postoperative pain as well (P<0.001). It was associated with a significant increase in somnolence (P=0.007) and dizziness (P=0.019), however, no significant difference in vomiting (P=0.075) was observed. Conclusion: A total dose of 3000 mg gabapentin before and during the first 24h after surgery, reduces pain score and pethidine consumption, and increases the incidence of somnolence and dizziness.