تأثير تيزانيدين خوراكي بر درد بعد از عمل جراحي

Effect of oral Tizanidine on post operative pain

Background: Tizanidine is a clonidine derivative and a2-adrenoreceptor agonist that has the same effects (sedation, anxiolysis and analgesia) but lesser side effects (hypotension and bradycardia ). In this study effects of oral tizanidine on post operative pain was evaluated. Materials and methods: In this clinical trial double blind study sixty patients (ASA I,II), aged 18-60yr, were randomly allocated into two groups. 90 minutes before induction of anesthesia both control and tizanidine group received placebo and 4mg oral tizanidine respectively. Pain severity and sedation score were assessed before and after receiving placebo or tizanidine and in the first 24hr post operative period. Meperidine requirements were assessed. Results: Pain severity and meperidine requirements in the tizanidine group were significantly lower than that in the control group (p<0.001). Sedation score was significantly higher than that in the tizanidine group (p<0.001). Conclusion: It was possible to reduce the post operative pain by oral administration of 4 mg tizanidine as premedication. Therefore, we recommend premedication with tizanidine for patients undergoing surgery