ضرورت ادغام واكسن MMR در برنامه واكسيناسيون روتين كشوري

The Necessity of MMR Vaccination as part of the National Routine Vaccination Program

Back ground and Objectives: Mumps is an acute, contagious disease which is self-limiting, benign and with a very low incidence rate. It is mostly seen in the children in the age group of 5 through 9. Vaccination yields to a long-term (persistent) immunity in more than 95% of people. Maternal antibody passes through placenta and provides immunity in the infancy period (first year of life).Thus the vaccination time can be scheduled any time after one-year age. The goal of this study was to evaluate the immunity situation of different age groups in terms of mumps. Materials and methods: During the study 1440 blood sample were taken from those people inhabitant in different parts of the country. For everybody a questionnaire including personal information and vaccination background was also filled out. All samples were centrifuged in the central laboratory then using refrigerator transferred to reference laboratory in the "Virology Department" of School of Public Health at Tehran University of Medical Sciences. In the reference lab, all the samples were investigated for antibody against mumps virus. Finally the data were statistically analyzed with the aid of SPSS program. Results: Totally, 1440 samples were collected from 829 male (57.6%) and 611 female (42.4%) who 971 of those (67.4%) were inhabitant of cities. The investigation revealed that 1144 people (79.4%) had antibody against mumps (with a 95% Confidence interval of 77.3%- 81.5%) versus 296 people (20.6%) with negative antibody result. The relevant frequency was highest in the age group of 6-10. Describing the frequencies of positive and negative samples for antibody in terms of different age groups, revealed the lest frequent group in the age of 1-5 (36.7%) and the most frequent one in the group of 26-40 (91.7%). The positive samples were more frequent in females than males (81.2% versus 77.1%) (p=0.057). On the other hand urban inhabitant had positive samples more than rural people (80% versus 78.3%), although the difference was not significant (p=0.44). On the whole, in economically deprived areas the positive antibody samples were the most (83.7%). And the difference between economically rich and underprivileged areas were statistically significant (p=0.002). Conclusion: Considering the following factors, the vaccination against mumps deems necessary: 1- The capability of health system of the country to reach a coverage rate of more than 95% for those diseases included in the expanded program for immunization (EPI) in I.R. Iran.