بررسي ارتباط بين ميزان هورمون گنادوتروپين جفتي در سه ماهه دوم بارداري و ابتلا به پره اكلامپسي

Relationship between human chorionic gonadotrapin (HCG) level in second trimester pregnancy and preeclampsia

Background and aim: Many researches have shown a relationship between levels of PHCG in pregnancy and preeclampsia, which can be used as a method for early diagnosis. The aim of this study was to determine relationship between levels of HCG in second trimester of pregnancy and preeclampsia. Methods: This study was conducted as a Nested case control study. Blood samples were taken from 1200 pregnant women who were in their second trimester of pregnancy and were admitted for prenatal care in Arak prenatal clinics. After isolation of serums, blood samples were stored in -20°C until delivery time. Finally serum HCG levels, blood pressure, proteinurea, edema, seizure and neonate statue were analyzed in 50 preeclamptic women (case group) and were compared with 50 normotensive women (control group). Accepted: 3/Dec/2009 1 Corresponding author: Midwifery Dept., Arak Univ. of Med. Sci. Sardasht, Arak, Iran. Tel: 0861-4173502-7 Email: n.akbary@arakmu.ac.ir Results: All women were complicated with mild preeclampsia. The mean of the PHCG in preeclamptic women was 43.08±32.56 Iu/ml and means of HCG in normotensive women was 27.48±25.97 mu/ml (P<0.05), the mean of systolic blood pressure in case and control groups were 144.09±11.30 mmHg and 110.26±8.13 mmHg, respectively (P<0.001). The mean of diastolic blood pressure in preeclamptic women was higher than normotensive women (90.45±4.34 mm/hg and 70±9.80 mm/hg) (P<0.001). Conclusion: Our data showed a significant relationship between mean levels of HCG preeclampsia in second trimester. Therefore, screening of high risk group with HCG hormone and careful prenatal care should be considered during pregnancy.