بررسي تاثير پلي مورفيسم 629C/A- ژن پروتيين انتقال دهنده كلسترول استر در ارتباط با اثر استاتين ها بر سطح ليپوپروتيين با دانسيته بالا (HDL)

Study of -629C/A polymorphism of cholesteryl ester transfer protein gene in statin effects on plasma high density lipoprotein cholesterol level.

Background and aim: Cholesteryl ester transfer protein (CETP) plays in HDL metabolism and in reverse cholesterol transport (RCT) pivotal role pathway. CETP gene variants such as -629C/A that affect HDL cholesterol directly, modulates CETP gene transcriptional activity. This study was aimed to determine influence of -629C/A polymorphism of CETP in statin effects with regard to plasma HDL cholesterol levels. Methods: In this descriptive-analytical study, 196 adult patients with LDL-C more than 120mg/dL were divided into two groups base on lovastatin and atorvastatin using. Lipid profile was measured in all subjects before and after treatment and -629C/A polymorphism of CETP promoter was studied using polymerase chain reaction/restriction fragment length polymorphism method. Data were compared with paired t-test and ANOVA in SPSS software. Results: Cholesterol was decreased and HDL was increased in AA genotype more than other genotypes by lovastatin, but ApoAl was increased in CC genotype. ApoAl also was increased in CC genotype more than AA or AC genotypes by atorvastatin. Conclusion: In CC genotype, lovastatin and specially atorvastatin increased ApoAl in HDL particles more than other genotypes. Therefore, treatment with lovastatin and atorvastatin is more effective in patients with CC genotype for raising HDL particles activity.