بررسي اثر تزريق درون بطني مغزي عصاره الكلي گياه علف چاي در بروز رفتار ترس در رت

Effect of alcoholic extract of Hypericum perforatum on fear behavior in adult male rats

Fear is a biologic response that protects animal from acute danger. Fear and anxiety is important matter in psychological science. Different mechanism and drug were introduced for their control and therapy. Herbal drugs have mild effects on fear and more sedative than chemical drugs. In this research the effect of intracerebroventricular (I. C. V) microinjection of Hypericum perforatum on fear were studied. Animals were divided into 5 groups: saline, Pentylenetetrazole (PTZ) 20mg/kg as positive control (i.p) and three groups that received 5,10, 20Mg/rat alcoholic extraction of H. perforatum (ICV) respectively. A cannul was placed in to lateral ventricle by Stereotaxic apparatus. After recovery period, Elevate plus maze were used for evaluation of the fear. Percent open arm entries (%OAE) and Percent of open arm time (%OAT) was evaluated. Our result showed that 10 |ig/rat and 20 |ig/rat doses increased %OAE and %OAT significantly (P<0001). We concluded that alcoholic extraction of H. perforatum effective drug in fear reduction. It probably acts on serotonergic and GAB Aergic system and decreases their reuptakes. By this mechanism decreased fear. Vet.J.of Islamic.Azad.Univ., Garmsar Branch. 3,4:207-115,2007.