بررسي اثر ان – استيل - سيستيين در كاهش ويسكوزيته مايع مني

The effects of N- acetyl-1- cysteine on reduction of semen viscosity

Background: Hyperviscous semen is an etiologic cause for male-related infertility which is related to function of oxidative systems in the cells. So, use of anti-oxidants may be useful. Hence, this study was conducted to evaluate the efficacy of N-acetyl-l-cysteine in reduction of seminal viscosity. Materials and methods: In this experimental study, 200 patients attending to urology clinic of Amiralmomenin hospital with hyperviscouse semen were selected and treated with N-acetyl-l-cysteine, 500 mg twice a day for one month. Sperm analysis was repeated after treatment and 10 days later. Results: After treatment, the viscosity which was initially high in all patients was normal in 124 men (62%), high in 60 patients (30%), and low in 16 subjects (8%). Also sperm count, motility, and morphology were improved significantly after the treatment (p< 0.05). Conclusion: According to 70 percent efficacy for Nacetyl-l-cysteine and lack of any drug adverse effects, this therapeutic modality may be indicated upon with patientʹs conditions and physicianʹs opinion.