كازيين فسفو پپتيد- آمورفوس كلسيم فسفات و نقش آن در سلامت دهان و دندان

Casein Phosphopeptides in oral and dental health

Casein Phosphopeptides (CPP-ACP) is a bioactive agent with the base of milk products, which have formed from two parts CPP and ACP.CPP produced from the milk protein casein and have a remarkable ability to stabilize calcium phosphate in solution and substantially increase the level of calcium phosphate in dental plaque. CPP-ACP buffers the free calcium and phosphate ion activities, thereby helps to maintain a state of super saturation with respect to tooth enamel depressing demineralization and enhancing remineralization. The free ca-p ions move out of the CPP, enter the enamel rods and reform onto apatite crystals.Laboratory, animal and human studies have shown that CPP-ACP exhibit cariogenic activity, treatment of white spot lesions, hypo mineralized enamel, mild fluorosis, tooth sensitivity, erosion, and prevent plaque accumulation around brackets and other orthodontic appliances. This agent facilitates the normal post-eruptive maturation process is derived from cowʹs milk and is ideal for protecting deciduous teeth at a time when oral care is difficult.This product is fluoride free and is especially useful for under 2ʹs where toxicological issues mean normal or high strength fluoride products are contraindicated; it is safe to swallow. This agent have commercial potential as an additive to foods, soft drinks, chewing gum as well as to toothpastes and mouthwashes for the control of dental caries.This article reviews the mechanism of action and therapeutic effects of CPP-ACP.