افزايش سطح سرمي فعاليت آنزيم آلكالين فسفاتاز در معتادين مصرف كننده ي كريستال

Studying the Increase of Activity Level of Serum Alkaline Phosphatase in Crystal Addicts

Introduction Crystal is one the pernicious addictive drugs which has unfortunately been imported to Iran in the recent years. As Crystal is the purified form of Heroin, its adverse effects are much more serious than those of Heroin. Apart from psychological effects, addiction to Crystal may have adverse effects on organs and tissues. So, the evaluation of enzymatic changes could be helpful in identifying the origin of damages. Alkaline phosphatase is present in most tissues and the most prevalent cause of its elevation is liver and bone diseases. Since liver damages may be caused by Heroin consumption, assaying ALP levels could be useful for investigating the adverse effects of this drug.Materials This study is a case control study which was carried out on 50 and control persons and 108 crystal addicts who referred toMethods Salehabad Center of Drug Addiction Treatment (Torbat jam) for the first time during 2008-2010. The activity level of Alkaline phosphatase in the serum was measured with Calorimetry-Spectrophotometry Using computer software SPSS-16, t-test was used to analyze the data.Results The results of this study indicate that there is a significant relationship between Crystal consumption and the serum level of ALP in both groups (P= 0.001). Besides, the relationships between the duration of Crystal consumption with Alkaline phosphatase level and cigarette smoking were significant.Conclusion Our results revealed that Crystal consumption is an important factor for elevating the ALP serum level in Crystal addicts.