مطالعه ي ميزان هورمون هاي FSH و LH روز سوم سيكل قاعدگي و تاثير آن بر روي تعداد و كيفيت اووسيت ها در خانم هاي نابارور كانديد سيكل روش هاي كمك باروري

A Study of Day Three FSH and LH Level on the Quantity and Quality of Oocytes in Infertile Women Candidates forART Cycle

Introduction Gonadptropins are the main regulators of women menstrual cycles during which the process of ovulation occurs. Also, infertile women with high level of FSH are poor responders to ovulation during ART cycles and often do not get good results. This Study tends to evaluate the effects of day three FSH and LH level on the number and quality of fertilized oocytes in infertile women who were candidates for ART cycle. The findings of this study may help the physicians to have better prediction about their patientsʹ responses to the treatment.Materials This is an experimental meta-analysis on 59 women who and referred to the Infertility Center for ART treatment. On the Methods third day of menstrual cycles, FSH and LH levels were measured using radioimmunoassay technique and their effects on the quality and quantity of oocytes as well as the pregnancy rate were evaluated. Then, having categorized the rate of FSH and LH into four groups, the data were examined, using SPSS, Version 16. Results After the treatment, the average levels of FSH and LH were measured as 9.01±7.8 and 7.56±7.27, respectively. The number of oocytes was found to be 10.29+7.88. It was also found that FSH level had meaningful relationship with pregnancy rate, oocytes number, oocytes number during Metaphase II, oocytes of quality A and fertilized oocytes. However, LH level had no meaningful effect on the results. Conclusion In this study, it was found that as the FSH level increases, the number and quality of oocytes, fertilized ooctyes and pregnancy rate increase. The best result can be seen in FSH=10-15 miu/ml. An increase in the level of LH also improved the effects where the best result can be seen in LH >8. In other words, the maximum number of fertilized ooctyes with the quality of grade A and grade B and the least number of grade C quality were observed. Therefore, it can be concluded that day three FSH and LH level can predict the results of ART cycles.