اثر تمرين استقامتي پيوسته بر IFN-γ ،IL-4و نسبت +CD4+/CD8 در موش هاي مبتلا به تومور سرطان سينه

Effect of Continuous Aerobic Exercise on the Rate of IL-4, IFN-y and Proportion of CD4+/CD8+ in Mice with Breast Cancer Tumor

This research was carried out to evaluate the effect of continuous aerobic exercise on the rate of IL-4, IFN-y and proportion of CD4+/CD8+ in mice with breast cancer tumor. For this reason 80 female balb/c mice were utilized and randomly divided in 4 groups as follow: 1: Exercise - Tumor - Exercise, 2: Exercise -Tumor - Rest, 3: Rest - Tumor - Exercise and 4: Rest -Tumor - Rest. Pre - tumor exercise regimen was done for 8 weeks at 50 % to 75% Vo2max and Post - tumor exercise regimen was done for 4 weeks at 50% Vo2max. The results of this research showed that the rate of inflammation cytokine, IL-4, decreased significantly in ETE and RTE groups (P<0.05). Data analysis showed that there were no significant differences between groups at the amount of effector cytokine production, IFN-y, and CD4+/CD8+ proportion after doing exercise programs (P>0.05). Based on the results of this research; doing continuous aerobic exercise is effective procedure for decreasing of inflammation factors such as IL-4. However this program is not a suite regimen for improving of effecter action of immune T cells.