مقايسه اثرات استراديول و پروژسترون اگزوژن بر سطح سرمي انسولين در موشهاي صحرايي ماده

ACOMPARISON BETWEEN THE EFFECTS OF EXOGENOUS ESTRADIOL OR PROGESTERONE ON SERUM INSULIN LEVEL IN FEMALE RATS

Female sex steroids play a pivotal role in regulation of insulin secretion. The main aim of this study was to determine the effects of female sex steroids on serum insulin in rats.Materials and Methods: Female rats were divided to control, oophorectomised, and progesterone or estradiol receiving animals. Progesterone (20 mg/kg/day) or estradiol valerate (200|ig/kg/day) were injected subcutaneously in female rats. After 4 weeks, serum insulin was measured and compared statistically between the groups (ANOVA). Results: Oophorectomy, and progesterone administration caused to decreasing of serum insulin (P<0.001) but estradiol administration resulted in increasing of serum insulin level (P<0.001). Conclusion: Progesterone replacement could not prohibit, however, estradiol valerate replacement prohibited the decreasing of insulin secretion following oophorectomy (PO.OOl). Sci.Res.Bio.J.of. Islam.Azad.univ.,Garmsar Branch. 2, 2:6-12,2007