تداخل عمل ضد دردي تزريق درون صفاقي همزمان عصاره آبي ميوه رازيانه (Foeniculum vulgare) و مرفين در موش سوري

تداخل عمل ضد دردي تزريق درون صفاقي همزمان عصاره آبي ميوه رازيانه (Foeniculum vulgare) و مرفين در موش سوري

Morphine for years as an analgesic drug is used, but given that the repeated administration of morphine is associated with dependence and tolerance, recent studies try is to administration of aqueous extract of fennel, along with its analgesic effect of morphine and the strengthening of reduce its consumption. This experimental study performed on 80 male mice (28±3g). Animals were grouped randomly in to control, positive control and receivers of Foeniculum vulgare extract. Control group and positive control group received normal saline 0.9% and indomethacin (5mg/kg, i.p.), respectively. Treatments groups were injected with doses, (100 mg/kg, i.p.), (200 mg/kg, i.p.) and (400 mg/kg, i.p.) of aqeous extract of Foeniculum vulgare. Animals were injected with acetic acid 0.6% (10ml/kg) for iducing of visceral pain, 30 minutes after of each intraperitoneal administration. Antinociceptive effect was recorded by counting the number of writhes immediately after injection of acetic acid during 30 minutes. In following treatments interaction of morphine in the antinociceptive effects of Foeniculum vulgare extract were studied with treatment of morphine (2mg/kg, i.p.) 15 minute after the administration of the extract in writhing test. this study showed that aqueous extract of F. vulgare at 100, 200 and 400 mg/kg and indomethacin (5mg/kg) induced a significant reduction in pain response compared to the control group (p<0.001). morphine (2mg/kg, i.p.) also coused antinociception and the concurrent use of F. vulgare and morphine produced more remarkable antinociception compared to their individual usages (p<0.001). Foeniculum vulgare and morphine also showed synergistic drug interaction for antinociception in the writhing test.