ارتباط نشانگر Ki67با شدت راكتيويتي و محل سرطان داخل اپي­تليوم دهانه رحم

The Correlation between Ki67 Proliferative Marker and the Reactivity and Site of Cervical Intraepithelial Lesions

Abstract Introduction: Cervical iulraepiihelml neoplasia and cancerous lesions arc spectrum ■.■! morphologic changes wilhoui having definite boundaries. Immtmohy biochemical methods and proliferative markers are among the reliable ways in classifying the various lesions of cervical dysplasia. It. related lite at ure ki6~ ;>roli erative •• rkct is ; -.it j ■■. .:. > . tctoi i the progression of cervical cancerous lesions. This research was performed lo propound a more del. • 1 ■ ■ ■: i■. i i■ ■ l o 1 v i ■■ i c \ p re sioi ■ ■ ʹ-.■■ʹ imiifemtke n irket. Methods: In this cross-sectional descriptive-analytical study 42 cervical biopsies (mild dysplasia N~11), moderate dysplasia N H. severe dysplasia N= 11) cervical normal tissue N ^ i were .selected from Pathology archive of Ghaem Hospital in Masllhad in year 2007, and the expression of Ki67 proliferative marker was analyzed hjstochemically in paralTimzed slides . Then the relationship between tiie severity of dyspl isia. the lo-..:. • n nl expression of 1. i6 .ʹ. -I I ■ r- actb ik c- the cervical dysplasia was exnni tied. Data w i- ana!; ■ ; t y SPSM a .1 tesinu /•.ʹ•.A tesls. Results: Thi direct relationship between the severity of dysplasia changes and (he site and reactivity of eer\ ical intraepithelial lesions was obsei ■ ed by using the opressiun of KI67 marker Conclusion: Evaluating intraepithelial cervical lesions by ImmunohistochemMrv methods and Ki67 marker is a reliable method for diagnosis and classify alion of various dysplastic lesions.