عنوان مقاله :
بررسي اثر حفاظتي ورزش بر پراكسيداسيون ليپيدي و تغييرات بافت شناسي در آسيب قلبي ايجاد شده توسط ايزوپزوترنول در موش صحرايي نر
عنوان به زبان ديگر :
Preventive Effect of Exercise on Lipid Peroxidation and Histopathological Changes in Isoproterenol-Induced myocardial infarction in Male Rats
پديد آورندگان :
سليماني، جعفر نويسنده دانشگاه علوم پزشكي تبريز,مركز تحقيقات كاربردي دارويي soleymani, jafar , محمدي، مصطفي نويسنده ,دانشگاه بقيه الله,اروميه,ايران mohammadi, mostafa , افشين، سليمه نويسنده afshin, salimeh , محدث، گيسو نويسنده mohades, gisou , رشيدي ، بهمن نويسنده rashidi, bahman
كليدواژه :
ورزش , پراكسيداسيون ليپيدي , ايزوپروترنول , موش صحرايي
چكيده لاتين :
isoproterenol (ISO) are associated with, and possibly due to, lipid peroxidation in heart tissue. In this study, the effect of exercise against lipid peroxidation and injuries due to isoproterenol was investigated in rat heart. Methods: 50 Wistar rats were divided into 5 groups: control rats (C), saline (S), Exercise (E), ISO injected (150 mg/kg) (ISO), Exercise + ISO (E+ISO), at the end of the experiment all animals anesthetized and heart tissue were collected for biochemical and histological examinations. Results: Exercise increased GSH (Glutathione), GSSG (Oxidized Glutathione) and decreased TBARS (Thiobarbituric Acid Reactive Substances) levels in ISO group (p<0.05). Also, exercise reduced the rate of edema, inflammatory cells infiltration and degree of necrosis compared with control group. Conclusion: Our results show exercise by reduction of lipid peroxidation and intensity of myocardial injuries may have beneficial protective effects against injuries due to isoproterenol.
Key words: Exercise, Lipid peroxidation, Isoproterenol, Rat.
كلمات كليدي :
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